Medication Holidays, ADHD, and the outdoors in Working with Kids Posted March 29, 2007 LongHaul, It all depends on the drug and how the person reacts being off the drug. Some drugs have longer halflives then others, meaning it takes longer for the system to get rid of one drug compared to another drug. In comparision, some drugs require 1,2 or even 3 weeks to even get up to theraputic levels before they start to work. If side effects is the concern and reason for breaks, try some of the newer med's on the market. My one son can't handle any stimulants at all because they send him manic. The other son didn't tolerate Aderal but had no problem with Concerta, apetite was good, never lost his sense of humor, never had personality changes associated with Ritalin. 60-90 days, My brother says now that he hated when my parents did that to him. He would rather have stayed on the drugs. It takes 2-3 weeks to get it all out. If you start it the week school starts, the your not giving the drug enough time to build up to working levels. It's better to leave them on the med's and if there are side effects look at other drug options. How do the kids act when off the drug is another consideration.